The problem of maternal toxicity in developmental toxicity studies
نویسندگان
چکیده
منابع مشابه
The problem of maternal toxicity in developmental toxicity studies.
Guidelines for developmental toxicity studies require that the highest dose(s) should induce some signs of maternal toxicity. However, the interpretation of the results is often difficult when developmentally toxic effects are recorded only at maternotoxic doses, as it is impossible to ascertain whether the developmental effects are maternally mediated or not. In order to avoid this source of m...
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ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 2012
ISSN: 0273-2300
DOI: 10.1016/j.yrtph.2011.11.021